Is tumor necrosis factor a physiological mediator?
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چکیده
منابع مشابه
Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions
We examined the role of cytokines in the cutaneous response to the application of trinitrochlorobenzene (TNCB) in both nonsensitized and sensitized mice, i.e., in the irritant reaction (IR) and contact hypersensitivity reactions (CH). When administered immediately before challenge, anti-tumor necrosis factor (TNF) antibody abrogated the ear swelling response in CH; antibody directed against int...
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The use of trovafloxacin (TVX), a fluoroquinolone antibiotic, was severely restricted because of an association of TVX therapy with idiosyncratic hepatotoxicity in patients. The mechanisms underlying idiosyncratic toxicity are unknown; however, one hypothesis is that an inflammatory stress can render an individual sensitive to the drug. Previously, we reported that treatment of mice with TVX an...
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Macrophages (Me/» can be activated to show highly selective cytotoxicity toward malignant cells in vitro [6, 8, 9, 13, 14] and there is some evidence that they may destroy neoplastic cells in vivo [1]. The importance of activated Me/> (aMe/» in controlling tumor growth in vivo has been further implicated in experiments involving murine ultraviolet light (UV)-induced tumors, which are highly imm...
متن کاملEvaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملTumor necrosis factor and anti-tumor necrosis factor therapies.
Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-...
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ژورنال
عنوان ژورنال: Immunology Today
سال: 1984
ISSN: 0167-5699
DOI: 10.1016/0167-5699(84)90071-9